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Kaposi's sarcoma typically occurs in immunocompromised patients, especially those with acquired immunodeficiencysyndrome. Human herpesvirus 8 (HHV-8) and human immunodeficiency virus (HIV) may play important roles in the developmentof Kaposi's sarcoma. We report the case of a 75-year-old male who presented with progressive multiple purplish papules andnodules on the skin for 3 months. Social and past medical histories seemed incompatible with an immunesuppressed condition andtests for HIV antibodies and HHV-8 were negative. He was newly diagnosed with rheumatoid arthritis, according to the 2010ACR-EULAR criteria. Typical findings of Kaposi's sarcoma were confirmed by biopsy. After treatment with metronomic oraletoposide 25 mg once daily for 9 months, the skin lesions had almost resolved with no serious complication. Thus, we report a rarecase of Kaposi’s sarcoma developing in a patient with newly diagnosed rheumatoid arthritis who showed a good response to oraletoposide.