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Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome that manifests as a variety of benign and malignanttumors in various organs. Notably, renal cell carcinoma (RCC) in patients with VHL disease tends to be multifocal and bilateral,and tends to recur or new tumors develop after removal. Radiofrequency ablation (RFA) has recently been introduced as aminimally invasive treatment for small hereditary RCCs with a low complication rate and a minimal decrease in renal function. Wepresent a case of successful RFA of multiple bilateral RCCs in a 24-year-old female with VHL. Computed tomography (CT) of theabdomen revealed multiple bilateral RCCs. The patient received sequential RFA for the bilateral RCCs, resulting in a completeresponse. At the time of writing, there was no sign of recurrence or renal failure. In conclusion, percutaneous RFA is a promisingtreatment for VHL patients who cannot undergo surgery, with excellent treatment outcomes and minimal change in renal function.