초록 열기/닫기 버튼
안구건조, 구강건조를 호소하는 환자를 진료할 때 흔하지는 않지만 쇼그렌증후군의 가능성을 염두에 두어야 한다. 특히 일차성 쇼그렌증후군 환자의 약 절반가량은 관절통, 레이노현상 등의 다양한 샘외증상이 나타날 수 있음을 인식해야한다.
Sjögren’s syndrome is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands resulting in a dry mouth and eyes. The disease can present either alone or in association with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and inflammatory myopathy. In addition to symptoms caused by exocrinopathy, about half of patients present with extraglandular (systemic) manifestations including arthritis, Raynaud’s phenomenon, lymphadenopathy, vasculitis, peripheral neuropathy, and interstitial nephritis. Patients often suffer from severe fatigue, myalgia, and dryness, which lead to a poor quality of life. Physicians should be aware of the increased risk of lymphoma development in patients with Sjögren’s syndrome. Currently, there are no drugs available that are able to improve the natural course of disease, making symptom relief the primary goal of therapy. Currently, pilocarpine is the only drug clinically proven for the treatment of dry eyes and mouth in patients with Sjögren’s syndrome.
키워드열기/닫기 버튼
Sjögren’s syndrome, Autoimmune diseases, Extraglandular manifestations, Lymphoma, Pilocarpine
