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Myasthenia gravis (MG) is often complicated by respiratory failure, known as a myasthenic crisis. However,most of the patients who develop respiratory symptoms do so during the late course of disease and have other neurological signs and symptoms. However, in some patients respiratory failure is the initial presenting symptom. We report the case of a 68-year-old woman with MG who presented with isolated respiratory failure as her first presenting symptom. As illustrated by this case, it is important to consider neuromuscular disorders in cases of unexplained respiratory failure. (Korean J Intern Med 2010;25:101-104)