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Knowledge and its creation receives more attention as a key ingredient for urban development in recent knowledge economy era. Interestingly, knowledge creation is dominated by a few cities according to OECD’s international patent statistics. This paper aims to analyze urban characteristics of knowledge creation by comparing cities over the world. Specifically, this paper investigates the relationship between technology international patents(OECD, 2008) and urban characteristics including economic, urban, and social attributes(Global Urban Competitiveness Report, 2010 and World Bank, 2008). The analysis finds that cities with (1) higher human capital(more educated people), (2) more business services, (3) higher urban livability(better climate environment, more health care service, and stronger local public finance) yield more knowledge creation.