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This study deals with a paradigm shift on business in the digital business world. The study focuses on the information technology and information system management. The study explores the current business environment in order to identify the new trend of management and economic paradigm, specifically the spirit era, care economy, service science, ubiquitous environment, and green business and environment management. The business entities can be strong competitors or winners in the digital business world by tailoring the changing of current business and technology environment, and by leading the changes and transformation. The study analysis can be applied to any other decision making situation in manufacturing and service operations. A practical approach of establishing the business solution is applicable to a new business expansion and transformation. This study supports policy-maker and decision-maker by providing strategic business insights.