@article{ART001981424,
author={김현범 and 권병재 and 조현지 and 김지원 and 천정우 and 도문호 and 박상용 and 김선여 and 맹성호 and 박유경 and 박지호},
title={Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency},
journal={Experimental Neurobiology},
issn={1226-2560},
year={2015},
volume={24},
number={1},
pages={71-83}
}

TY - JOUR
AU - 김현범
AU - 권병재
AU - 조현지
AU - 김지원
AU - 천정우
AU - 도문호
AU - 박상용
AU - 김선여
AU - 맹성호
AU - 박유경
AU - 박지호
TI - Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency
T2 - Experimental Neurobiology
JO - Experimental Neurobiology
PY - 2015
VL - 24
IS - 1
PB - 한국뇌신경과학회
SP - 71
EP - 83
SN - 1226-2560
AB - Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus and much less in a model of ovarian hormone deficiency. We examined the influence of chronic oral AP ethanol extract treatment in ovariectomized rats on the induction of long-term depression in a representative synapse (CA3-CA1) of the hippocampus. Ovariectomized rats demonstrated lower trabecular mean bone mineral densities than sham, validating the establishment of pathology. Against this background of pathology, AP-treated ovariectomized rats exhibited attenuated long-term depression (LTD) in CA1 relative to water-treated controls as measured by increased field excitatory post-synaptic potentials (fEPSP) activation averages over the post-stimulation period. While pathological significance of long-term depression (LTD) in ovariectomized rats is conflicting, that AP treatment significantly affected its induction offers justification for further study of its influences on plasticity and its related disorders
KW - Artemisia princeps, Oriental medicine, ovariectomy, long-term depression (LTD), hippocampal synaptic plasticity
DO -
UR -
ER -

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경 and 박지호. 2015, "Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency", Experimental Neurobiology, vol.24, no.1 pp.71-83.

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경, 박지호 "Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency" Experimental Neurobiology 24.1 pp.71-83 (2015) : 71.

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경, 박지호. Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency. 2015; 24(1), 71-83.

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경 and 박지호. "Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency" Experimental Neurobiology 24, no.1 (2015) : 71-83.

김현범; 권병재; 조현지; 김지원; 천정우; 도문호; 박상용; 김선여; 맹성호; 박유경; 박지호. Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency. Experimental Neurobiology, 24(1), 71-83.

김현범; 권병재; 조현지; 김지원; 천정우; 도문호; 박상용; 김선여; 맹성호; 박유경; 박지호. Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency. Experimental Neurobiology. 2015; 24(1) 71-83.

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경, 박지호. Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency. 2015; 24(1), 71-83.

김현범, 권병재, 조현지, 김지원, 천정우, 도문호, 박상용, 김선여, 맹성호, 박유경 and 박지호. "Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency" Experimental Neurobiology 24, no.1 (2015) : 71-83.