@article{ART001950353,
author={Abid Oueslati and Methodios Ximerakis and Kostas Vekrellis},
title={Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation},
journal={Experimental Neurobiology},
issn={1226-2560},
year={2014},
volume={23},
number={4},
pages={324-336}
}

TY - JOUR
AU - Abid Oueslati
AU - Methodios Ximerakis
AU - Kostas Vekrellis
TI - Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation
T2 - Experimental Neurobiology
JO - Experimental Neurobiology
PY - 2014
VL - 23
IS - 4
PB - 한국뇌신경과학회
SP - 324
EP - 336
SN - 1226-2560
AB - Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteinsplay a central role in the initiation and the progression of several neurodegenerative disorders. This “prion-like” hypothesis hasbeen recently reported for α-synuclein, a presynaptic protein implicated in the pathogenesis of Parkinson’s disease (PD) and relateddisorders. This review summarizes recent findings on α-synuclein prion-like propagation, focusing on its transmission, seeding anddegradation and discusses some key questions that remain to be explored. Understanding how α-synuclein exits cells and propagatesfrom one brain region to another will lead to the development of new therapeutic strategies for the treatment of PD, aiming atslowing or stopping the disease progression.
KW - secretion, seeding, turnover, extracellular proteins, disease propagation
DO -
UR -
ER -

Abid Oueslati, Methodios Ximerakis and Kostas Vekrellis. 2014, "Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation", Experimental Neurobiology, vol.23, no.4 pp.324-336.

Abid Oueslati, Methodios Ximerakis, Kostas Vekrellis "Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation" Experimental Neurobiology 23.4 pp.324-336 (2014) : 324.

Abid Oueslati, Methodios Ximerakis, Kostas Vekrellis. Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. 2014; 23(4), 324-336.

Abid Oueslati, Methodios Ximerakis and Kostas Vekrellis. "Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation" Experimental Neurobiology 23, no.4 (2014) : 324-336.

Abid Oueslati; Methodios Ximerakis; Kostas Vekrellis. Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. Experimental Neurobiology, 23(4), 324-336.

Abid Oueslati; Methodios Ximerakis; Kostas Vekrellis. Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. Experimental Neurobiology. 2014; 23(4) 324-336.

Abid Oueslati, Methodios Ximerakis, Kostas Vekrellis. Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. 2014; 23(4), 324-336.

Abid Oueslati, Methodios Ximerakis and Kostas Vekrellis. "Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation" Experimental Neurobiology 23, no.4 (2014) : 324-336.