@article{ART001199439,
author={Byung Tae Ahn and Sung Ahn Shin and Jun Gi Kim and Won Hwan Park},
title={Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells},
journal={동의생리병리학회지},
issn={1738-7698},
year={2007},
volume={21},
number={1},
pages={243-249}
}

TY - JOUR
AU - Byung Tae Ahn
AU - Sung Ahn Shin
AU - Jun Gi Kim
AU - Won Hwan Park
TI - Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells
T2 - 동의생리병리학회지
JO - 동의생리병리학회지
PY - 2007
VL - 21
IS - 1
PB - 한의병리학회
SP - 243
EP - 249
SN - 1738-7698
AB - The French paradox has been attributed to the antioxidant properties of flavonoids present in the red wine. Amentoflavone(AF) is a bi-flavonoid compound with anti-fungal and anti-inflammatory activities. We isolated AF from Selaginella tamariscina, and studied its effects on nuclear factor-B(NF-B)-mediated MMP-9 gene expression in RAW264.7 cells. AF blocked the lipopolysaccharide(LPS)-induced expression of MMP-9. Zymographic and immunoblot analyses showed that AF suppressed LPS-induced MMP-9 expression in a dose-dependent manner. To clarify the mechanistic basis for its inhibition of MMP-9 induction, we examined the effect of AF on the transactivation of MMP-9 gene by luciferase reporter activity using −1.59 kb flanking region. AF potently suppressed the reporter gene activity. This inhibition was characterized by down-regulation of MMP-9, which was transcriptionally regulated at NF-B site and activation protein-1 (AP-1) site in the MMP-9 promoter, two important nuclear transcription factors that are involved in MMP-9 expression. These findings indicate the efficacy of AF in inhibiting MMP-9 expression through the transcription factors NF-B and AP-1 on LPS-induced RAW264.7 cells.
KW - MMP-9, NF-κB, AP-1, Amentoflavone, Selaginella tamariscina, LPS
DO -
UR -
ER -

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim and Won Hwan Park. 2007, "Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells", 동의생리병리학회지, vol.21, no.1 pp.243-249.

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim, Won Hwan Park "Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells" 동의생리병리학회지 21.1 pp.243-249 (2007) : 243.

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim, Won Hwan Park. Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells. 2007; 21(1), 243-249.

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim and Won Hwan Park. "Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells" 동의생리병리학회지 21, no.1 (2007) : 243-249.

Byung Tae Ahn; Sung Ahn Shin; Jun Gi Kim; Won Hwan Park. Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells. 동의생리병리학회지, 21(1), 243-249.

Byung Tae Ahn; Sung Ahn Shin; Jun Gi Kim; Won Hwan Park. Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells. 동의생리병리학회지. 2007; 21(1) 243-249.

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim, Won Hwan Park. Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells. 2007; 21(1), 243-249.

Byung Tae Ahn, Sung Ahn Shin, Jun Gi Kim and Won Hwan Park. "Inhibitory Effect of Amentoflavone of Selaginella Tamariscina on MMP-9 Expression through NF-κB and AP-1 in Macrophage Raw 264.7 cells" 동의생리병리학회지 21, no.1 (2007) : 243-249.