@article{ART000962458,
author={Sung Min Ju and Kun Jung Kim and Jong Gil Lee and Chai Ho Lee and Dong Min Han and Young Gab Yun and Gi Yun Hong and Won Gun An and Byung Hun Jeon},
title={CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release},
journal={동의생리병리학회지},
issn={1738-7698},
year={2005},
volume={19},
number={3},
pages={802-810}
}

TY - JOUR
AU - Sung Min Ju
AU - Kun Jung Kim
AU - Jong Gil Lee
AU - Chai Ho Lee
AU - Dong Min Han
AU - Young Gab Yun
AU - Gi Yun Hong
AU - Won Gun An
AU - Byung Hun Jeon
TI - CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release
T2 - 동의생리병리학회지
JO - 동의생리병리학회지
PY - 2005
VL - 19
IS - 3
PB - 한의병리학회
SP - 802
EP - 810
SN - 1738-7698
AB - The tetrahydroisoquinolines included potent cytotoxic agents that showed antitumor activity,antimicrobial activity, and other biological properties. We studied the effect of CDST, 1-Chloromethyl-6,7-dimethoxy-3,4-dihydro- 1H-isoquinoline-2-sulfonic acid amide, a newly synthesized anti-cancer agent. The cytotoxic activity of CDST in HL-60 cells was increased in a dose-dependent manner. CDST, tetrahydroisoquinolines derivative, was cytotoxic to HL-60 cells, with IC50 of 80㎍/㎖. Treatment of CDST to HL-60 cells showed the fragmentation of DNA in a dose- and time dependent manner, suggesting that thesecells underwent apoptosis. Treatment of HL-60 cells with CDST was induced in a dose- and time-dependent activation of caspase-3, caspase-8 and proteolytic cleavage of poly(ADP-ribose) polymerase. In caspase activity assay, caspase-3 and -8 was activated after 12 h and 6 h posttreatment, respectively. CDST also caused the release of cytochrome c from mitochondria into the cytosol. CDST-induced cytochrome c release was mediated by caspase-8-dependent cleavage of Bid and Bax translocation. These results suggest that caspase-8 induced Bid cleavage and Bax translocation, caused mitochondrial cytochrome c release, and induce caspase-3 activationduring CDST-induced apoptosis in HL-60 cells.
KW - CDST, Tetrahydroisoquinoline, Apoptosis, HL-60
DO -
UR -
ER -

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An and Byung Hun Jeon. 2005, "CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release", 동의생리병리학회지, vol.19, no.3 pp.802-810.

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An, Byung Hun Jeon "CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release" 동의생리병리학회지 19.3 pp.802-810 (2005) : 802.

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An, Byung Hun Jeon. CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release. 2005; 19(3), 802-810.

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An and Byung Hun Jeon. "CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release" 동의생리병리학회지 19, no.3 (2005) : 802-810.

Sung Min Ju; Kun Jung Kim; Jong Gil Lee; Chai Ho Lee; Dong Min Han; Young Gab Yun; Gi Yun Hong; Won Gun An; Byung Hun Jeon. CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release. 동의생리병리학회지, 19(3), 802-810.

Sung Min Ju; Kun Jung Kim; Jong Gil Lee; Chai Ho Lee; Dong Min Han; Young Gab Yun; Gi Yun Hong; Won Gun An; Byung Hun Jeon. CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release. 동의생리병리학회지. 2005; 19(3) 802-810.

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An, Byung Hun Jeon. CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release. 2005; 19(3), 802-810.

Sung Min Ju, Kun Jung Kim, Jong Gil Lee, Chai Ho Lee, Dong Min Han, Young Gab Yun, Gi Yun Hong, Won Gun An and Byung Hun Jeon. "CDST, a Derivative of Tetrahydroisoquinoline, Induced Apoptosis in HL-60 Cells through Activation of Caspase-8, Bid Cleavage and Cytochrome c Release" 동의생리병리학회지 19, no.3 (2005) : 802-810.