@article{ART000962457,
author={Ki Young Lee and Se Keun Park and Jeong Seon Kim and Mi Hyeon Jang and Chang Ju Kim and Sun Mi Choi and Hye Jung Lee and Ee Hwa Kim},
title={Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS},
journal={동의생리병리학회지},
issn={1738-7698},
year={2005},
volume={19},
number={3},
pages={785-791}
}

TY - JOUR
AU - Ki Young Lee
AU - Se Keun Park
AU - Jeong Seon Kim
AU - Mi Hyeon Jang
AU - Chang Ju Kim
AU - Sun Mi Choi
AU - Hye Jung Lee
AU - Ee Hwa Kim
TI - Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS
T2 - 동의생리병리학회지
JO - 동의생리병리학회지
PY - 2005
VL - 19
IS - 3
PB - 한의병리학회
SP - 785
EP - 791
SN - 1738-7698
AB - Corydalis Tuber has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Corydalis Tuber has been known to be effective for the control of pain and treatment of arthritis. It was reported that Corydalis Tuber possesses anti-inflammatory activity and modulates the intestinal immune system. The effect of Corydalis Tuber against LPS-stimulated expressions of COX-2, iNOS, and IL-1β in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), PGE2 immunoassay, and NO detection. The aqueous extract of Corydalis Tuber was shown to suppress PGE2 production by inhibition on the LPS-stimulated enhancement of COX-2 enzyme activity, IL-1β, and iNOS expression in the RAW 264.7 macrophages. Present results suggest that Corydalis Tuber exerts anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and IL-1β expressions, resulting in inhibition of PGE2 synthesis. Corydalis Tuber has anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and IL-1β mRNA expressions, resulting in inhibition of PGE2 and NO synthesis.
KW - Corydalis Tuber, COX-2, Inflammation, iNOS, PGE2
DO -
UR -
ER -

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee and Ee Hwa Kim. 2005, "Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS", 동의생리병리학회지, vol.19, no.3 pp.785-791.

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee, Ee Hwa Kim "Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS" 동의생리병리학회지 19.3 pp.785-791 (2005) : 785.

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee, Ee Hwa Kim. Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS. 2005; 19(3), 785-791.

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee and Ee Hwa Kim. "Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS" 동의생리병리학회지 19, no.3 (2005) : 785-791.

Ki Young Lee; Se Keun Park; Jeong Seon Kim; Mi Hyeon Jang; Chang Ju Kim; Sun Mi Choi; Hye Jung Lee; Ee Hwa Kim. Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS. 동의생리병리학회지, 19(3), 785-791.

Ki Young Lee; Se Keun Park; Jeong Seon Kim; Mi Hyeon Jang; Chang Ju Kim; Sun Mi Choi; Hye Jung Lee; Ee Hwa Kim. Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS. 동의생리병리학회지. 2005; 19(3) 785-791.

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee, Ee Hwa Kim. Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS. 2005; 19(3), 785-791.

Ki Young Lee, Se Keun Park, Jeong Seon Kim, Mi Hyeon Jang, Chang Ju Kim, Sun Mi Choi, Hye Jung Lee and Ee Hwa Kim. "Effects of Corydalis Tuber on Synthesis of NO and PGE2 in Murine Macrophage RAW 264.7 Cells Stimulated by LPS" 동의생리병리학회지 19, no.3 (2005) : 785-791.