초록 열기/닫기 버튼
This study aimed to examine the effects of Samjahwadam-jeon (SJHDJ) on CD4+ T cells and CD8+ T cells in ovalbumin (OVA)-induced asthmatic mice. C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ (400 mg/kg and 200 mg/kg) extract and cyclosporin A (10 mg/kg) for the later 8 weeks. At the end of the experiment, the mice lung, peripheral lymph node (PLN), and spleen were removed and CD4+ T cells and CD8+ T cells for analyzed by flow cytometer. Number of CD4+ T cells in lung, PLN and spleen of the SJHDJ group (400 ㎎/㎏ and 200 ㎎/㎏) were significantly decreased compared with that of control group. Number of CD8+ T cells in PLN and spleen of the SJHDJ group (400 ㎎/㎏, 200 ㎎/㎏) were significantly decreased compared with that of control group. Conclusion : These results suggest that SJHDJ alleviated asthmatic hyperreactivity through CD4+ and CD8+ T cells. Further study of relative cytokines is expected..
