초록 열기/닫기 버튼
Procoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), thrombin-antithrombin complex (TAT), and plasminogen-antiplasmin complex (PAP). Circulating IL-6 levels were measured using ELISA (Quantikine, R & D systems, MN, USA). Circulating IL-6 (mean, 26.5pg/mL) and PAI-1 (mean, 19.9ng/mL) levels were higher in patients with acute stroke than in healthy subjects (mean, 3.0pg/mL, 10.4ng/mL, respectively). TAT levels were statistically different according to the etiologic subtypes of stroke (atherogenic, 2.5ng/mL; lacunar 3.2ng/mL; cardiogenic 9.9ng/mL, p=0.021). Neither procoagulant levels nor fibrinolytic markers significantly correlated with circulating IL-6 levels. Our findings suggest that elevated proinflammatory cytokines during the initial hours of ischemic stroke may be an independent pathogenic factor or a consequence of the thrombotic event with no relationship to the procoagulant or fibrinolytic states.
키워드열기/닫기 버튼
Stroke, cytokine, procoagulant, fibrinolysis
