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Purpose: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations betweenthe ALDH2 polymorphism and the risk of ALC. Materials and Methods: Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databasesup to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. Results: A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphismwas associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61–0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. Conclusion: The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
