초록 열기/닫기 버튼
Background: Skin infections with Gram-negative bacteriaare sometimes challenging to treat, because these bacteriashow multidrug resistance against commonly used antibioticsand patients with Gram-negative bacterial infection overallhave deteriorated in conditions in many cases. Studies haveshown that epigallocatechin gallate (EGCG) and green teaextracts (GTE) inhibit the growth of several Gram-positivebacteria species. Objective: The purpose of this study was toinvestigate the minimum inhibitory concentrations (MICs) ofEGCG and GTE in Pseudomonas aeruginosa and Escherichiacoli, and assess the use of these chemicals as an alternativeor adjunct topical antimicrobial agent against P. aeruginosaand E. coli with multidrug resistance. Methods: The MICs ofEGCG, GTE, and other tested antibiotics were measured andcompared to determine the antibacterial efficacy and thedifferences in pattern of resistance. Results: The P. aeruginosaand E. coli strains used in this study showed multidrugresistance. EGCG inhibited the growth of P. aeruginosa at aMIC level of 200∼400 μg/ml. The MIC of GTE was a 1 : 16dilution for P. aeruginosa. EGCG showed antimicrobialactivity against E. coli at a MIC of 400 μg/ml. In the case ofGTE, the MIC was a dilution between 1：8 and 1：4 for E. coli. Conclusion: EGCG and GTE showed potential asalternative or adjunct topical antimicrobial agents forinfections that are resistant to traditional antibiotic therapy.
