@article{ART001143545,
author={안명주 and 이기환 and 안준익 and 유동현 and 이혜숙 and 최정혜 and 장정순 and 배준민 and 이용성},
title={The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray},
journal={Cancer Research and Treatment},
issn={1598-2998},
year={2004},
volume={36},
number={1},
pages={43-49}
}

TY - JOUR
AU - 안명주
AU - 이기환
AU - 안준익
AU - 유동현
AU - 이혜숙
AU - 최정혜
AU - 장정순
AU - 배준민
AU - 이용성
TI - The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray
T2 - Cancer Research and Treatment
JO - Cancer Research and Treatment
PY - 2004
VL - 36
IS - 1
PB - 대한암학회
SP - 43
EP - 49
SN - 1598-2998
AB - PURPOSE: Adriamycin is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast cancer cells. MATERIALS AND METHODS: We have analyzed the MCF-7 breast cell line and its adriamycin-resistant variants, MCF-7/ADR using human 10 K element cDNA microarrays. RESULTS: We defined 68 genes that were up-regulated (14 genes) or down-regulated (54 genes) in adriamycin resistant breast cancer cells. Several genes, such as G protein-coupled receptor kinase 5, phospholipase A2, guanylate cyclase 1, vimentin, matrix metalloproteinase 1 are up-regulated in drug resistant cells. Several genes, such as interferon, alpha-inducible protein 27, forkhead box M1, mitogen-activated protein kinase 6, regulator of mitotic spindle assembly 1 and tumor necrosis factor superfamily are down-regulated in adriamycin resistant cells. The altered expression of genes observed in microarray was verified by RT-PCR. CONCLUSION: These findings show that cDNA microarray analysis can be used to obtain gene expression profiles reflecting the effect of anticancer drugs on breast cancer cells. Such data may lead to the assigning of signature expression profiles of drug-resistant tumors which may help predict responses to drugs and assist in the design of tailored therapeutic regimens to overcome drug resistance.(Cancer Res Treat. 2004;36:43-49)
KW - Breast cancer cells,Drug resistance,cDNA microarray,Adriamycin
DO -
UR -
ER -

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민 and 이용성. 2004, "The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray", Cancer Research and Treatment, vol.36, no.1 pp.43-49.

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민, 이용성 "The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray" Cancer Research and Treatment 36.1 pp.43-49 (2004) : 43.

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민, 이용성. The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray. 2004; 36(1), 43-49.

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민 and 이용성. "The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray" Cancer Research and Treatment 36, no.1 (2004) : 43-49.

안명주; 이기환; 안준익; 유동현; 이혜숙; 최정혜; 장정순; 배준민; 이용성. The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray. Cancer Research and Treatment, 36(1), 43-49.

안명주; 이기환; 안준익; 유동현; 이혜숙; 최정혜; 장정순; 배준민; 이용성. The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray. Cancer Research and Treatment. 2004; 36(1) 43-49.

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민, 이용성. The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray. 2004; 36(1), 43-49.

안명주, 이기환, 안준익, 유동현, 이혜숙, 최정혜, 장정순, 배준민 and 이용성. "The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray" Cancer Research and Treatment 36, no.1 (2004) : 43-49.