@article{ART000873315,
author={Kyung Seung Oh and Ki Uk Kim and Na Hee Park and Su Yeong Seo and Sun Seob Choi and Gi Yeong Huh},
title={Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse},
journal={Cancer Research and Treatment},
issn={1598-2998},
year={2002},
volume={34},
number={1},
pages={52-57}
}

TY - JOUR
AU - Kyung Seung Oh
AU - Ki Uk Kim
AU - Na Hee Park
AU - Su Yeong Seo
AU - Sun Seob Choi
AU - Gi Yeong Huh
TI - Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse
T2 - Cancer Research and Treatment
JO - Cancer Research and Treatment
PY - 2002
VL - 34
IS - 1
PB - 대한암학회
SP - 52
EP - 57
SN - 1598-2998
AB - Purpose: To obtain basic data for development of a glioblastoma-specific immunotoxin, the expression of variable cell surface receptors on a human glioblastoma xenograft model was evaluated, using NOD/SCID mice. Materials and Methods: We developed a xenograft model in NOD/SCID mice implanted with a human glioblastoma cell line (U-87MG). Immunohistochemical studies were performed on implanted tumor nodules (n=8) using antibodies against CD71, EGFR, IGF-IRα, CXCR4 and IL-4Rα. Results: Expression of IL-4Rα, in implanted tumor nodules, was the highest of the cell surface receptors evaluated in this study. However, the endothelial cells in, and around, the tumor nodules also revealed immunopositivity against IL-4Rα. The immunoreactivity of IL-4R α, and other surface receptors such as CD71, IGF-IRα and EGFR, was prominent in tumor nodules associated with tumor necrosis. Conclusion: IL-4Rα would be a possible target for the development of glioblastoma-specific immunotoxin, although there are limitations due to its endothelial expression. (Cancer Res Treat. 2002;34:52-57)
KW - Glioblastoma, Interleukin-4 receptor, SCID mouse
DO -
UR -
ER -

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi and Gi Yeong Huh. 2002, "Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse", Cancer Research and Treatment, vol.34, no.1 pp.52-57.

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi, Gi Yeong Huh "Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse" Cancer Research and Treatment 34.1 pp.52-57 (2002) : 52.

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi, Gi Yeong Huh. Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse. 2002; 34(1), 52-57.

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi and Gi Yeong Huh. "Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse" Cancer Research and Treatment 34, no.1 (2002) : 52-57.

Kyung Seung Oh; Ki Uk Kim; Na Hee Park; Su Yeong Seo; Sun Seob Choi; Gi Yeong Huh. Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse. Cancer Research and Treatment, 34(1), 52-57.

Kyung Seung Oh; Ki Uk Kim; Na Hee Park; Su Yeong Seo; Sun Seob Choi; Gi Yeong Huh. Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse. Cancer Research and Treatment. 2002; 34(1) 52-57.

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi, Gi Yeong Huh. Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse. 2002; 34(1), 52-57.

Kyung Seung Oh, Ki Uk Kim, Na Hee Park, Su Yeong Seo, Sun Seob Choi and Gi Yeong Huh. "Expression of Cell Surface Receptors on Human Glioblastoma Xenograft Model in NOD/SCID Mouse" Cancer Research and Treatment 34, no.1 (2002) : 52-57.