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The prevalence and pattern of drug-resistant extrapulmonary tuberculosis (TB) is not well characterized in Korea. Therefore, we assessed the incidence of drug resistance for extrapulmonary TB in adult patients at a tertiary hospital. We retrospectively reviewed the medical records and results of drug susceptibility test in all culture-confirmed extapulmonary TB patients during an 18-month period. Out of a total of 168 cases in which the drug susceptibility test was performed, resistance to at least one anti-TB drug was found in 15 cases (8.9%), and multidrug resistance, in which TB was resistant to at least isoniazid and rifampin, was found in 3 cases (1.8%).