초록 열기/닫기 버튼
Sepsis remains a leading cause of death in critically ill patients, despite efforts to improve patient outcome. Thus far, no magicdrugs exist for severe sepsis and septic shock. Instead, early diagnosis and prompt initial management such as early goal-directedtherapy are key to improve sepsis outcome. For early detection of sepsis, biological markers (biomarkers) can help cliniciansto distinguish infection from host response to inflammation. Ideally, biomarkers can be used for risk stratification, diagnosis,monitoring of treatment responses, and outcome prediction. More than 170 biomarkers have been identified as useful for evaluatingsepsis, including C-reactive protein, procalcitonin, various cytokines, and cell surface markers. Recently, studies have reportedon the usefulness of biomarker-guided antibiotic stewardships. However, the other side of these numerous biomarkers isthat no novel single laboratory marker can diagnose, predict, and track the treatment of sepsis. The purpose of this review is tosummarize several key biomarkers from recent sepsis studies.
