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Despite considerable evidence suggesting that physical characteristics, such as facial attractiveness, and psychological characteristics, such as personality and intelligence, are associated with mortality and health, few studies have integrated these factors into a single model. Using data from the Wisconsin Longitudinal Study (WLS), the present study explores which, and to what extent, individual characteristics are associated with various dimensions of health. Moreover, this study compares and contrasts the results from the WLS with results from the Americans’ Changing Lives (ACL) study. Results from parametric proportional hazard regressions indicate that, even after accounting for SES and health behavior risk factors, two personality traits – neuroticism and openness – matter for men’s mortality in the WLS. Also, higher levels of physical attractiveness significantly reduced the hazard of mortality for women. However, intelligence had a trivial effect on all health outcomes in both sexes. Similar patterns were observed in the ACL.