@article{ART001498028,
author={김미경 and 문영철 and 성주명 and 정화순 and 허정원},
title={Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH},
journal={Annals of Laboratory Medicine},
issn={2234-3806},
year={2010},
volume={30},
number={6},
pages={711-717}
}

TY - JOUR
AU - 김미경
AU - 문영철
AU - 성주명
AU - 정화순
AU - 허정원
TI - Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH
T2 - Annals of Laboratory Medicine
JO - Annals of Laboratory Medicine
PY - 2010
VL - 30
IS - 6
PB - 대한진단검사의학회
SP - 711
EP - 717
SN - 2234-3806
AB - A variant Philadelphia chromosome (Ph) is generated from translocation of one or more partner chromosomes in addition to chromosomes 9 and 22. We have described the cases of 2 patients bearing variant Ph detected by interphase FISH but not detected by G-banded karyotyping and metaphase FISH. FISH was performed using BCR/ABL dual color dual fusion translocation probes (Abbott Molecular, USA). A 52-year-old man was diagnosed with acute leukemia of mixed phenotype. G-banded karyotyping showed 46,XY,t(9;22)(q34;q11.2)[12]/47,idem,+der(22)t(9;22)[5]/46,XY[3]. Interphase FISH revealed nuc ish(ABL1,BCR)×3(ABL1 con BCR×2)[329/450]/(ABL1,BCR)×4(ABL1 con BCR×3)[5/450]/(AL1,BCR)×3(ABL1 con BCR×1)[44/450]. Metaphase FISH showed ish (9;22)(ABL1+,BCR1+;BCR+,ABL+)[22]/der(22)(BCR+,ABL1+)[3]. The other case was that of a 31-yr-old male patient diagnosed with CML in the blastic phase. G-banded karyotyping of all 20 metaphase cells showed 47,XYYc,dup(1)(q21q32),del(7)(p11.2),t(9;22)(q34;q11.2). Interphase FISH revealed nuc ish(ABL1,BCR)×3(ABL1 con BCR×2)[254/600]/(ABL1,BCR)×3(ABL1 con BCR×1)[191/600]. Metaphase FISH showed ish t(9;22)(ABL1+,BCR+;BCR+,ABL1+)[16]. These results suggest that typical t(9;22) and variant Ph may coexist in the same patient, and interphase FISH may facilitate the detection of the variant Ph that cannot be detected by G-banded karyotyping alone. (Korean J Lab Med 2010;30:711-7)
KW - Philadelphia chromosome, Variant, FISH, Interphase, Metaphase
DO -
UR -
ER -

김미경, 문영철, 성주명, 정화순 and 허정원. 2010, "Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH", Annals of Laboratory Medicine, vol.30, no.6 pp.711-717.

김미경, 문영철, 성주명, 정화순, 허정원 "Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH" Annals of Laboratory Medicine 30.6 pp.711-717 (2010) : 711.

김미경, 문영철, 성주명, 정화순, 허정원. Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH. 2010; 30(6), 711-717.

김미경, 문영철, 성주명, 정화순 and 허정원. "Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH" Annals of Laboratory Medicine 30, no.6 (2010) : 711-717.

김미경; 문영철; 성주명; 정화순; 허정원. Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH. Annals of Laboratory Medicine, 30(6), 711-717.

김미경; 문영철; 성주명; 정화순; 허정원. Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH. Annals of Laboratory Medicine. 2010; 30(6) 711-717.

김미경, 문영철, 성주명, 정화순, 허정원. Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH. 2010; 30(6), 711-717.

김미경, 문영철, 성주명, 정화순 and 허정원. "Variant Philadelphia Chromosome Identified by Interphase Fluorescence In Situ Hybridization (FISH) without Evidence on G-banded Karyotyping and Metaphase FISH" Annals of Laboratory Medicine 30, no.6 (2010) : 711-717.