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Apraxia of eyelid opening is a well-known and occasionally observed condition in the hemispheric lesions. However, apraxia of eyelid closure, which is characterized by difficulty in voluntary eyelids closing with normal blinkings, is very rare. We report a patient with moyamoya disease who developed eyelid closing apraxia accompanied by motor impersistence. Brain magnetic resonance imaging study showed recent infarctions in the bilateral frontal lobes and the right basal ganglia. The lesion of the bilateral frontal lobes was suggested to be responsible for the apraxia and motor impersistence of eyelid closing.