연구배경 지방간으로 진단된 성인에서 대사증후군의 동반에 대한 체질량지수, 허리둔부둘레비(WHR), 체지방률의 예측력을 평가하였다. 방 법 2005년 3월~2006년 6월동안 건강증진센터에서 초음파로 지방간으로 진단된 1030명 성인(남자 708명, 여자 322명)에서 체질량지수 및 생체전기저항법으로 WHR과 체지방률을 평가하였다. 대사증후군은 고혈압, 고혈당, 저HDL, 고중성지방혈증 중 세가지 이상일 때로 정의하였다. BMI(25kg/m2)와 WHR(남자에서 0.9, 여자에서 0.85) 조합에 따라 4개 군으로 구분하였다. 결 과 성별, 연령, 지방간 수준, 학력을 보정한 대사증후군에 대한 교차비는 비만이 아니고 WHR이 낮은 군보다 비만은 아니지만 WHR이 높은 군에서 1.7(95% 신뢰구간 0.9-3.4), 비만이고 WHR이 낮은 군에서 4.4(2.4-7.7), 비만이고 WHR이 높은 군에서 3.9(2.2-6.7) 이었다. ROC 분석에서 대사증후군을 예측하는 적정 체질량지수, WHR, 체지방률은 남자에서 27kg/m2, 0.93, 24%, 여자에서 24kg/m2, 0.88, 33%이었다. 세 측정방법의 민감도는 70~90%, 특이도는 30~60%이었다. area under the curve는 남자에서 체질량지수, WHR, 체지방률 간에 유의한 차이가 없지만 여자에서 체지방률은 체질량지수, WHR에 비해 유의하게 작았다. 결 론 체질량지수와 WHR은 지방간이 있을 때 대사증후군을 예측하는 지표로 유용할 것으로 보이며, 체질량지수 25kg/m2 이상이면 예측력이 가장 높았다.

Background To evaluate predictability of body mass index(BMI), waist-to-hip ratio(WHR), and percent body fat(%BF) for metabolic syndrome(MS). Methods A total of 1030 adults(708 males, 322 females) diagnosed as fatty liver by ultrasound from a health promotion center during the period between March 2005 and June 2006 were subjects. BMI was measured, and WHR and %BF were assessed using bioelectrical impedance analyzer. MS was defined as having at least three metabolic components (high blood pressure, glucose and TG, and low HDL). BMI levels(<25kg/m2 vs. ≥25kg/m2) and WHR levels(<0.9 vs. ≥0.9 for males, <0.85 vs.≥0.85 for females) were combined to make 4 categories.Applied prominent thesis, journals, studies, and e-media, this review is based on final definitions that has been proven so far. Results The odds ratio(95% C.I) for having MS was 1.7(0.9-3.4) in group of high WHR/low BMI, 4.4(2.4-7.7) in group of low WHR/high BMI, 3.9(2.2-6.7) in group of high WHR/high BMI compared to the group of low WHR/low BMI. Using ROC analyses for MS, the cutoff values of BMI, WHR, and %BF were 27kg/m2, 0.93, 24% for males, and 24kg/m2, 0.88, 33% for females, respectively. The sensitivity and specificity were 70~90% and 30~60%, respectively. There were no significant differences in the area under the curves(AUC) among BMI, WHR, and %BF in males, while AUC for %BF was significantly lower compared with those for BMI and WHR in females. Conclusions Both of BMI and WHR would be useful indicators for predicting MS in adults with fatty liver and BMI of 25kg/m2 would be an adequate cutoff value.

Background To evaluate predictability of body mass index(BMI), waist-to-hip ratio(WHR), and percent body fat(%BF) for metabolic syndrome(MS). Methods A total of 1030 adults(708 males, 322 females) diagnosed as fatty liver by ultrasound from a health promotion center during the period between March 2005 and June 2006 were subjects. BMI was measured, and WHR and %BF were assessed using bioelectrical impedance analyzer. MS was defined as having at least three metabolic components (high blood pressure, glucose and TG, and low HDL). BMI levels(<25kg/m2 vs. ≥25kg/m2) and WHR levels(<0.9 vs. ≥0.9 for males, <0.85 vs.≥0.85 for females) were combined to make 4 categories.Applied prominent thesis, journals, studies, and e-media, this review is based on final definitions that has been proven so far. Results The odds ratio(95% C.I) for having MS was 1.7(0.9-3.4) in group of high WHR/low BMI, 4.4(2.4-7.7) in group of low WHR/high BMI, 3.9(2.2-6.7) in group of high WHR/high BMI compared to the group of low WHR/low BMI. Using ROC analyses for MS, the cutoff values of BMI, WHR, and %BF were 27kg/m2, 0.93, 24% for males, and 24kg/m2, 0.88, 33% for females, respectively. The sensitivity and specificity were 70~90% and 30~60%, respectively. There were no significant differences in the area under the curves(AUC) among BMI, WHR, and %BF in males, while AUC for %BF was significantly lower compared with those for BMI and WHR in females. Conclusions Both of BMI and WHR would be useful indicators for predicting MS in adults with fatty liver and BMI of 25kg/m2 would be an adequate cutoff value.

Fatty liver, metabolic syndrome, body mass index, waist-to-hip ratio, percent body fat